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Comparative Analysis of Mesenchymal Stem Cell Exosome Regenerative Potential in Wound Healing

This investigation examined the therapeutic promise of nano-sized vesicles secreted by mesenchymal stem cells (MSCs) sourced from bone marrow, adipose tissue, and umbilical cord. These exosomes carry vital bioactive molecules—including DNA fragments, microRNAs, proteins, and lipids—that orchestrate critical wound healing processes like cellular division, migration, and angiogenesis. Our findings demonstrate that all three MSC-derived exosome types contain essential regenerative mediators such as VEGF-A, FGF-2, HGF, and PDGF-BB. Notably, TGF-β emerged exclusively in umbilical cord MSC exosomes, highlighting origin-specific bioactivity. Experimental doses up to 20 μg showed dose-dependent enhancement of keratinocyte and fibroblast movement, with BMMSC exosomes driving strongest fibroblast activation and UCMSC exosomes optimizing keratinocyte responses. Clinical relevance suggests these exosome profiles could translate into novel biologic therapies for chronic wound management.

Authors: Bui H.T.H; Hoang D.H; Nguyen H.P; Nguyen X.H; Dam P.T.M; Trinh M.Q; Vu D.M; Thanh L.N; Than U.T.T and colleagues

Explore full publication at NCBI Article
View author profile Dr. Nguyen X.H Publications

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  • Health Sciences

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Research Management Advisor Position[Job opportunity] Research Management Advisor

Posted January 30, 2026

[Job opportunity] Research Management Advisor

VinUniversity seeks meticulous finance professionals to maintain rigorous fiscal oversight in rapidly expanding academic operations. Candidates will manage comprehensive budget evaluations, ensure regulatory adherence, and support strategic financial planning under executive leadership.

About VinUniversity: As Vietnam's premier private institution founded by Vingroup, we cultivate global talent through cutting-edge research initiatives addressing national development priorities.

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Responsibilities include managing institutional budgets, enforcing accounting protocols, and enabling operational efficiency across departments. Ideal candidates demonstrate exceptional organizational skills and commitment to financial excellence within innovative educational ecosystems.

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